New developments in the pharmacological modulation of wound healing after glaucoma filtration surgery

Graphical abstract Highlights ► Scarring is the major cause of surgical failure for glaucoma surgery including new devices. ► Current anti-scarring agents have an increased risk of blinding complications. ► New approaches to the inhibition of different pathways may yield efficacious safer alternativ...

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Veröffentlicht in:	Current opinion in pharmacology 2013-02, Vol.13 (1), p.65-71
Hauptverfasser:	Lockwood, Alastair, Brocchini, Stephen, Khaw, Peng Tee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Animals Fibroblasts - cytology Fibroblasts - physiology Filtering Surgery Glaucoma - drug therapy Glaucoma - metabolism Glaucoma - surgery Humans Inflammation - metabolism Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Matrix Metalloproteinase Inhibitors - pharmacology Matrix Metalloproteinases - metabolism Medical Education Vascular Endothelial Growth Factor A - antagonists & inhibitors Wound Healing - drug effects
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► Scarring is the major cause of surgical failure for glaucoma surgery including new devices. ► Current anti-scarring agents have an increased risk of blinding complications. ► New approaches to the inhibition of different pathways may yield efficacious safer alternatives.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.10.008