Densanins A and B, New Macrocyclic Pyrrole Alkaloids Isolated from the Marine Sponge Haliclona densaspicula

Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively...

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Veröffentlicht in:	Organic letters 2012-12, Vol.14 (24), p.6154-6157
Hauptverfasser:	Hwang, Buyng Su, Oh, Jung Soon, Jeong, Eun Ju, Sim, Chung J, Rho, Jung-Rae
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Diamines - chemistry Diamines - isolation & purification Diamines - pharmacology Haliclona - chemistry Lipopolysaccharides - pharmacology Marine Biology Mice Microglia - drug effects Molecular Structure Nitric Oxide - biosynthesis Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology Republic of Korea
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Zusammenfassung:	Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC50 values of 1.05 and 2.14 μM, respectively.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol3028303