Three-Component Reaction of Propargyl Amines, Sulfonyl Azides, and Alkynes: One-Pot Synthesis of Tetrasubstituted Imidazoles

Three-Component Reaction of Propargyl Amines, Sulfonyl Azides, and Alkynes: One-Pot Synthesis of Tetrasubstituted Imidazoles

An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-Sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2012-12, Vol.14 (24), p.6266-6269
Hauptverfasser: Jiang, Zheng, Lu, Ping, Wang, Yanguang
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Azides - chemistry
Catalysis
Imidazoles - chemical synthesis
Imidazoles - chemistry
Molecular Structure
Pargyline - analogs & derivatives
Pargyline - chemistry
Propylamines - chemistry
Sulfones - chemical synthesis
Sulfones - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-Sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303023y