Introducing Ligand-Based Hydrogen Bond Donors to a Receptor: Both Selectivity and Binding Affinity for Anion Recognition in Water Can Be Improved

Introducing Ligand-Based Hydrogen Bond Donors to a Receptor: Both Selectivity and Binding Affinity for Anion Recognition in Water Can Be Improved

Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3–ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a ma...

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Veröffentlicht in:Journal of organic chemistry 2012-12, Vol.77 (24), p.11405-11408
Hauptverfasser: Huang, Feihu, Cheng, Chen, Feng, Guoqiang
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates. Nucleosides and nucleotides
Chemistry
Coordination compounds
Diphosphates - chemistry
Exact sciences and technology
Hydrogen Bonding
Inorganic chemistry and origins of life
Ligands
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Preparations and properties
Substrate Specificity
Water - chemistry
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Zusammenfassung:Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3–ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many metalloenzymes.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo302271t