A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients
The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified...
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| Veröffentlicht in: | American journal of transplantation 2012-11, Vol.12 (11), p.3061-3068 |
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| container_title | American journal of transplantation |
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| creator | Chinnock, R. Webber, S. A. Dipchand, A. I. Brown, R. N. George, J. F. |
| description | The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified as PTLD. Overall freedom from PTLD was 98.5% at 1 year, 94% at 5 years and 90% at 10 years. Freedom from PTLD was lowest in children (ages 1 to < 10 years) versus infants ( |
| doi_str_mv | 10.1111/j.1600-6143.2012.04197.x |
| format | Article |
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Epstein–Barr virus status and the age of the recipient at the time of transplantation are important variables in the development of posttransplant lymphoproliferative disorder in the pediatric heart transplant recipient.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2012.04197.x</identifier><identifier>PMID: 23072522</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Age ; Age Distribution ; Age Factors ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; EBV ; Epstein-Barr virus ; Epstein-Barr Virus Infections - epidemiology ; Epstein-Barr Virus Infections - etiology ; Epstein-Barr Virus Infections - physiopathology ; Female ; Graft Rejection ; Graft Survival ; hazard ; Heart ; Heart Transplantation - adverse effects ; Heart Transplantation - methods ; Herpesvirus 4, Human - isolation & purification ; Humans ; Infant ; Infectious diseases ; Kaplan-Meier Estimate ; lymphoma ; Lymphoproliferative Disorders - epidemiology ; Lymphoproliferative Disorders - etiology ; Lymphoproliferative Disorders - physiopathology ; Male ; Medical sciences ; Miscellaneous ; outcomes ; Pediatrics ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Prevalence ; Proportional Hazards Models ; PTLD ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk Assessment ; Sex Distribution ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival Analysis ; Time Factors ; Transplants & implants ; Viral diseases</subject><ispartof>American journal of transplantation, 2012-11, Vol.12 (11), p.3061-3068</ispartof><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2014 INIST-CNRS</rights><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5767-45b70ae6d231c3d8634105e24766fcb3dac794887173383dcb0768ba4e1153</citedby><cites>FETCH-LOGICAL-c5767-45b70ae6d231c3d8634105e24766fcb3dac794887173383dcb0768ba4e1153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2012.04197.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2012.04197.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26735991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23072522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chinnock, R.</creatorcontrib><creatorcontrib>Webber, S. A.</creatorcontrib><creatorcontrib>Dipchand, A. I.</creatorcontrib><creatorcontrib>Brown, R. N.</creatorcontrib><creatorcontrib>George, J. F.</creatorcontrib><creatorcontrib>Pediatric Heart Transplant Study</creatorcontrib><title>A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified as PTLD. Overall freedom from PTLD was 98.5% at 1 year, 94% at 5 years and 90% at 10 years. Freedom from PTLD was lowest in children (ages 1 to < 10 years) versus infants (<1 year) and adolescents (10 to < 18 years) with children at highest risk for PTLD with a relative risk of 2.4 compared to infants and 1.7 compared to adolescents. Positive donor EBV status was a strong risk factor for PTLD in the seronegative recipient, but risk magnitude was dependent on recipient age at the time of transplantation. Nearly 25% of EBV seronegative recipients of EBV+ donors at ages 4–7 at transplantation developed some form of PTLD. The overall risk for PTLD declined in the most recent transplant era (2001–2009, p = 0.003). These findings indicate that EBV status and the age of the recipient at the time of transplantation are important variables in the development of PTLD in the pediatric heart transplant recipient.
Epstein–Barr virus status and the age of the recipient at the time of transplantation are important variables in the development of posttransplant lymphoproliferative disorder in the pediatric heart transplant recipient.</description><subject>Adolescent</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>EBV</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Epstein-Barr Virus Infections - etiology</subject><subject>Epstein-Barr Virus Infections - physiopathology</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>hazard</subject><subject>Heart</subject><subject>Heart Transplantation - adverse effects</subject><subject>Heart Transplantation - methods</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Kaplan-Meier Estimate</subject><subject>lymphoma</subject><subject>Lymphoproliferative Disorders - epidemiology</subject><subject>Lymphoproliferative Disorders - etiology</subject><subject>Lymphoproliferative Disorders - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>outcomes</subject><subject>Pediatrics</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Prevalence</subject><subject>Proportional Hazards Models</subject><subject>PTLD</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Transplants & implants</subject><subject>Viral diseases</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-O0zAQxiMEYpeFV0CWEBKXBv-LnRw4ZJeFLSpiVSokTpZjTxZXqVNiR2xv3LjyjDwJDi1F4rS-zFj-zXzj-bIMEZyTdF6ucyIwngnCWU4xoTnmpJL57b3s9Phw_5iz4iR7FMIaYyJpSR9mJ5RhSQtKT7MfNSLi1_efn0EP6P3YRZcucx-ii2N0vdcd-hhHu0N9i-IXQMu-gymvbwBpb9Hl-acE6DgG1Ht0vVq8RnNvnAVvANWb3t-ga7BOx8EZdJVEIloN2odtp31ESzBu68DH8Dh70OouwJNDPMuWby5XF1ezxYe384t6MTOFFHLGi0ZiDcJSRgyzpWCc4AIol0K0pmFWG1nxspREMlYyaxosRdloDoQU7Cx7sW-6HfqvI4SoNi4Y6NIs0I9BEZqqikoW9A4oJYRjSnlCn_2HrvtxSJtL1KRa4RQSVe4pM_QhDNCq7eA2etgpgieOqLWa_FKTd2oyVf0xVd2m0qcHgbHZgD0W_nUxAc8PgA5Gd21asHHhHydk-lU1zfBqz31zHezuPICq362mjP0GS0i7mQ</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Chinnock, R.</creator><creator>Webber, S. A.</creator><creator>Dipchand, A. I.</creator><creator>Brown, R. N.</creator><creator>George, J. F.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients</title><author>Chinnock, R. ; Webber, S. A. ; Dipchand, A. I. ; Brown, R. N. ; George, J. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5767-45b70ae6d231c3d8634105e24766fcb3dac794887173383dcb0768ba4e1153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>EBV</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - epidemiology</topic><topic>Epstein-Barr Virus Infections - etiology</topic><topic>Epstein-Barr Virus Infections - physiopathology</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>hazard</topic><topic>Heart</topic><topic>Heart Transplantation - adverse effects</topic><topic>Heart Transplantation - methods</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Kaplan-Meier Estimate</topic><topic>lymphoma</topic><topic>Lymphoproliferative Disorders - epidemiology</topic><topic>Lymphoproliferative Disorders - etiology</topic><topic>Lymphoproliferative Disorders - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>outcomes</topic><topic>Pediatrics</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Prevalence</topic><topic>Proportional Hazards Models</topic><topic>PTLD</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Transplants & implants</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chinnock, R.</creatorcontrib><creatorcontrib>Webber, S. A.</creatorcontrib><creatorcontrib>Dipchand, A. I.</creatorcontrib><creatorcontrib>Brown, R. N.</creatorcontrib><creatorcontrib>George, J. 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A.</au><au>Dipchand, A. I.</au><au>Brown, R. N.</au><au>George, J. F.</au><aucorp>Pediatric Heart Transplant Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2012-11</date><risdate>2012</risdate><volume>12</volume><issue>11</issue><spage>3061</spage><epage>3068</epage><pages>3061-3068</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified as PTLD. Overall freedom from PTLD was 98.5% at 1 year, 94% at 5 years and 90% at 10 years. Freedom from PTLD was lowest in children (ages 1 to < 10 years) versus infants (<1 year) and adolescents (10 to < 18 years) with children at highest risk for PTLD with a relative risk of 2.4 compared to infants and 1.7 compared to adolescents. Positive donor EBV status was a strong risk factor for PTLD in the seronegative recipient, but risk magnitude was dependent on recipient age at the time of transplantation. Nearly 25% of EBV seronegative recipients of EBV+ donors at ages 4–7 at transplantation developed some form of PTLD. The overall risk for PTLD declined in the most recent transplant era (2001–2009, p = 0.003). These findings indicate that EBV status and the age of the recipient at the time of transplantation are important variables in the development of PTLD in the pediatric heart transplant recipient.
Epstein–Barr virus status and the age of the recipient at the time of transplantation are important variables in the development of posttransplant lymphoproliferative disorder in the pediatric heart transplant recipient.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>23072522</pmid><doi>10.1111/j.1600-6143.2012.04197.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of transplantation, 2012-11, Vol.12 (11), p.3061-3068 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Age Age Distribution Age Factors Biological and medical sciences Child Child, Preschool Cohort Studies EBV Epstein-Barr virus Epstein-Barr Virus Infections - epidemiology Epstein-Barr Virus Infections - etiology Epstein-Barr Virus Infections - physiopathology Female Graft Rejection Graft Survival hazard Heart Heart Transplantation - adverse effects Heart Transplantation - methods Herpesvirus 4, Human - isolation & purification Humans Infant Infectious diseases Kaplan-Meier Estimate lymphoma Lymphoproliferative Disorders - epidemiology Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - physiopathology Male Medical sciences Miscellaneous outcomes Pediatrics Postoperative Complications - diagnosis Postoperative Complications - epidemiology Prevalence Proportional Hazards Models PTLD Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Assessment Sex Distribution Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Survival Analysis Time Factors Transplants & implants Viral diseases |
| title | A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients |
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