A 16‐Year Multi‐Institutional Study of the Role of Age and EBV Status on PTLD Incidence Among Pediatric Heart Transplant Recipients

The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified...

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Veröffentlicht in:	American journal of transplantation 2012-11, Vol.12 (11), p.3061-3068
Hauptverfasser:	Chinnock, R., Webber, S. A., Dipchand, A. I., Brown, R. N., George, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Age Distribution Age Factors Biological and medical sciences Child Child, Preschool Cohort Studies EBV Epstein-Barr virus Epstein-Barr Virus Infections - epidemiology Epstein-Barr Virus Infections - etiology Epstein-Barr Virus Infections - physiopathology Female Graft Rejection Graft Survival hazard Heart Heart Transplantation - adverse effects Heart Transplantation - methods Herpesvirus 4, Human - isolation & purification Humans Infant Infectious diseases Kaplan-Meier Estimate lymphoma Lymphoproliferative Disorders - epidemiology Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - physiopathology Male Medical sciences Miscellaneous outcomes Pediatrics Postoperative Complications - diagnosis Postoperative Complications - epidemiology Prevalence Proportional Hazards Models PTLD Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Assessment Sex Distribution Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Survival Analysis Time Factors Transplants & implants Viral diseases
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Beschreibung
Zusammenfassung:	The objective was to determine the incidence and hazard for posttransplant lymphoproliferative disease (PTLD) in a study of 3170 pediatric primary heart transplants between 1993 and 2009 at 35 institutions in the Pediatric Heart Transplant Study. 147 of 151 reported malignancy events were classified as PTLD. Overall freedom from PTLD was 98.5% at 1 year, 94% at 5 years and 90% at 10 years. Freedom from PTLD was lowest in children (ages 1 to < 10 years) versus infants (
ISSN:	1600-6135 1600-6143
DOI:	10.1111/j.1600-6143.2012.04197.x