Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT

Summary Objective Vitamin D deficiency is a worldwide health problem. Usual supplements are inadequate for prevention of hypovitaminosis D, and much higher doses are needed for its treatment. This study was designed to compare the efficacy and practicality of high‐dose intramuscular and oral choleca...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2013-02, Vol.78 (2), p.210-216
Hauptverfasser:	Zabihiyeganeh, Mozhdeh, Jahed, Adel, Nojomi, Marzieh
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Biological and medical sciences Cholecalciferol - administration & dosage Cholecalciferol - adverse effects Cholecalciferol - therapeutic use Drug Administration Schedule Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Injections, Intramuscular Male Medical sciences Middle Aged Vertebrates: endocrinology Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - drug therapy
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Zusammenfassung:	Summary Objective Vitamin D deficiency is a worldwide health problem. Usual supplements are inadequate for prevention of hypovitaminosis D, and much higher doses are needed for its treatment. This study was designed to compare the efficacy and practicality of high‐dose intramuscular and oral cholecalciferol in treatment of hypovitaminosis D and to evaluate durability of the effect of each remedy. Design Ninety‐two patients with hypovitaminosis D [serum 25(OH) D level
ISSN:	0300-0664 1365-2265
DOI:	10.1111/j.1365-2265.2012.04518.x