Lupus Nephritis: Treatment of Resistant Disease

Lupus Nephritis: Treatment of Resistant Disease

Lupus nephritis (LN) remains a major cause of ESRD and is associated with a >4-fold increase in mortality and significant morbidity in patients with lupus. The treatment of LN has evolved significantly over the past decade due to data from well conducted randomized controlled trials. We are curre...

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Veröffentlicht in:Clinical journal of the American Society of Nephrology 2013-01, Vol.8 (1), p.154-161
Hauptverfasser: Kalloo, Sean, Aggarwal, Nidhi, Mohan, Prince, Radhakrishnan, Jai
Format: Artikel
Sprache:eng
Schlagworte:
Drug Resistance
Humans
Immunosuppressive Agents - therapeutic use
Lupus Nephritis - drug therapy
Lupus Nephritis - mortality
Morbidity
Randomized Controlled Trials as Topic
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Zusammenfassung:Lupus nephritis (LN) remains a major cause of ESRD and is associated with a >4-fold increase in mortality and significant morbidity in patients with lupus. The treatment of LN has evolved significantly over the past decade due to data from well conducted randomized controlled trials. We are currently in an era in which effective regimens exist in the form of induction and maintenance agents. Histopathologic classification of LN remains one of the main factors guiding therapy.
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.05870612