Neutrophil–lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment

Background & Aims Although the Milan criteria (MC) have been used to select liver transplantation candidates among patients with hepatocellular carcinoma (HCC), many patients exceeding the MC have shown good prognosis. Preoperative neutrophil–lymphocyte ratio (NLR) is a predictor of patient prog...

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Veröffentlicht in:	Journal of hepatology 2013-01, Vol.58 (1), p.58-64
Hauptverfasser:	Motomura, Takashi, Shirabe, Ken, Mano, Yohei, Muto, Jun, Toshima, Takeo, Umemoto, Yuichiro, Fukuhara, Takasuke, Uchiyama, Hideaki, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Maehara, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Disease-Free Survival Female Gastroenterology and Hepatology HCC Humans IL 17 Interleukin-17 - metabolism Interleukin-8 - metabolism Kaplan-Meier Estimate Liver Neoplasms - immunology Liver Neoplasms - mortality Liver Neoplasms - surgery Liver transplantation Liver Transplantation - mortality Lymphocyte Count Lymphocytes - cytology Macrophages - cytology Male Middle Aged Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - mortality Neutrophils - cytology NLR Predictive Value of Tests Preoperative Care Prognosis Risk Factors TAM Tumor Microenvironment - immunology Vascular Endothelial Growth Factor A - metabolism Young Adult
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Zusammenfassung:	Background & Aims Although the Milan criteria (MC) have been used to select liver transplantation candidates among patients with hepatocellular carcinoma (HCC), many patients exceeding the MC have shown good prognosis. Preoperative neutrophil–lymphocyte ratio (NLR) is a predictor of patient prognosis, but its mechanism has never been clarified. Methods We assessed outcomes in 158 patients who had undergone living-donor liver transplantation (LDLT) for HCC. Recurrence-free survival (RFS) was determined in patients with high (⩾4) and low (
ISSN:	0168-8278 1600-0641
DOI:	10.1016/j.jhep.2012.08.017