Uterine leiomyosarcoma and Leser-Trélat sign
The mainstay of treatment is total abdominal hysterectomy and bilateral salpingo-oophorectomy.2 Gynaecological cancers have rarely been associated with cutaneous paraneoplasia.3 The Leser-Trélat sign is a cutaneous paraneoplastic syndrome characterised by the sudden appearance of numerous seborrhoei...
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| Veröffentlicht in: | The Lancet (British edition) 2013-01, Vol.381 (9860), p.88-88 |
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| creator | Abakka, Sanae, Dr Elhalouat, Hatim, MD Khoummane, Nadia, MD Achaaban, Mouad, MD ElAmrani, Sabah, Prof Bargach, Samir, Prof Yousfi, Mounia, Prof |
| description | The mainstay of treatment is total abdominal hysterectomy and bilateral salpingo-oophorectomy.2 Gynaecological cancers have rarely been associated with cutaneous paraneoplasia.3 The Leser-Trélat sign is a cutaneous paraneoplastic syndrome characterised by the sudden appearance of numerous seborrhoeic keratoses, or the rapid increase in size and number of preexisting lesions especially on the trunk. The importance of Leser-Trélat sign is under debate because seborrhoeic keratoses and cancers are both common in elderly people.4 Yet the sign is regarded by many investigators as an independent paraneoplastic syndrome which is supported by reports of eruptive seborrhoeic keratoses in young patients, and by a strong association with well recognised paraneoplastic syndromes, such as malignant acanthosis nigricans and tripe palms.3 Recogniton of the sign in cases of occult cancer is important and we suggest that patients presenting with Leser-Trélat sign be thoroughly investigated for internal malignancy, especially gynaecological cancers in women. |
| doi_str_mv | 10.1016/S0140-6736(12)61805-4 |
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The importance of Leser-Trélat sign is under debate because seborrhoeic keratoses and cancers are both common in elderly people.4 Yet the sign is regarded by many investigators as an independent paraneoplastic syndrome which is supported by reports of eruptive seborrhoeic keratoses in young patients, and by a strong association with well recognised paraneoplastic syndromes, such as malignant acanthosis nigricans and tripe palms.3 Recogniton of the sign in cases of occult cancer is important and we suggest that patients presenting with Leser-Trélat sign be thoroughly investigated for internal malignancy, especially gynaecological cancers in women.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(12)61805-4</identifier><identifier>PMID: 23290965</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Abdomen ; Aged ; Biological and medical sciences ; Female ; Female genital diseases ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; Keratosis, Seborrheic - complications ; Leiomyosarcoma - complications ; Leiomyosarcoma - diagnosis ; Medical sciences ; Ovarian cancer ; Paraneoplastic Syndromes - complications ; Tumors ; Uterine Neoplasms - complications ; Uterine Neoplasms - diagnosis ; Women</subject><ispartof>The Lancet (British edition), 2013-01, Vol.381 (9860), p.88-88</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 5, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-b7f77713f7315f0a141c36f2ec7809942213992eecd5e1c2e830ea644d5122b83</citedby><cites>FETCH-LOGICAL-c408t-b7f77713f7315f0a141c36f2ec7809942213992eecd5e1c2e830ea644d5122b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1315208734?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26780323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23290965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abakka, Sanae, Dr</creatorcontrib><creatorcontrib>Elhalouat, Hatim, MD</creatorcontrib><creatorcontrib>Khoummane, Nadia, MD</creatorcontrib><creatorcontrib>Achaaban, Mouad, MD</creatorcontrib><creatorcontrib>ElAmrani, Sabah, Prof</creatorcontrib><creatorcontrib>Bargach, Samir, Prof</creatorcontrib><creatorcontrib>Yousfi, Mounia, Prof</creatorcontrib><title>Uterine leiomyosarcoma and Leser-Trélat sign</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>The mainstay of treatment is total abdominal hysterectomy and bilateral salpingo-oophorectomy.2 Gynaecological cancers have rarely been associated with cutaneous paraneoplasia.3 The Leser-Trélat sign is a cutaneous paraneoplastic syndrome characterised by the sudden appearance of numerous seborrhoeic keratoses, or the rapid increase in size and number of preexisting lesions especially on the trunk. The importance of Leser-Trélat sign is under debate because seborrhoeic keratoses and cancers are both common in elderly people.4 Yet the sign is regarded by many investigators as an independent paraneoplastic syndrome which is supported by reports of eruptive seborrhoeic keratoses in young patients, and by a strong association with well recognised paraneoplastic syndromes, such as malignant acanthosis nigricans and tripe palms.3 Recogniton of the sign in cases of occult cancer is important and we suggest that patients presenting with Leser-Trélat sign be thoroughly investigated for internal malignancy, especially gynaecological cancers in women.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Keratosis, Seborrheic - complications</subject><subject>Leiomyosarcoma - complications</subject><subject>Leiomyosarcoma - diagnosis</subject><subject>Medical sciences</subject><subject>Ovarian cancer</subject><subject>Paraneoplastic Syndromes - complications</subject><subject>Tumors</subject><subject>Uterine Neoplasms - complications</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Women</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkM1KJDEQgIO46Kz6CMqACO6htSpJJ92XXRbZH2HAgwreQiZdLdH-0aRHmEfa59gX2_TMrIIXT7l8-arqY-wQ4QwB1fk1oIRMaaFOkX9RWECeyS02Qalllkt9t80mr8gu-xzjAwBIBfkO2-WCl1CqfMKy24GC72jakO_bZR9tcH1rp7arpjOKFLKb8PdPY4dp9PfdPvtU2ybSwebdY7c_f9xc_M5mV78uL77PMiehGLK5rrXWKGotMK_BokQnVM3J6QLKUnKOoiw5katyQsepEEBWSVnlyPm8EHvsdO19Cv3zguJgWh8dNY3tqF9Eg1wLrrSGET1-hz70i9Cl7Qym6RwKLWSi8jXlQh9joNo8Bd_asDQIZuxpVj3NGCvZzaqnGf8dbeyLeUvV66__ARNwsgFsdLapg-2cj2-cShcLLhL3bc1RyvbiKZjoPHWOKh_IDabq_YerfH1ncI3vfBr6SEuKb1ebyA2sJaMD-cogxT-3XKPN</recordid><startdate>20130105</startdate><enddate>20130105</enddate><creator>Abakka, Sanae, Dr</creator><creator>Elhalouat, Hatim, MD</creator><creator>Khoummane, Nadia, MD</creator><creator>Achaaban, Mouad, MD</creator><creator>ElAmrani, Sabah, Prof</creator><creator>Bargach, Samir, Prof</creator><creator>Yousfi, Mounia, Prof</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20130105</creationdate><title>Uterine leiomyosarcoma and Leser-Trélat sign</title><author>Abakka, Sanae, Dr ; Elhalouat, Hatim, MD ; Khoummane, Nadia, MD ; Achaaban, Mouad, MD ; ElAmrani, Sabah, Prof ; Bargach, Samir, Prof ; Yousfi, Mounia, Prof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-b7f77713f7315f0a141c36f2ec7809942213992eecd5e1c2e830ea644d5122b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>General aspects</topic><topic>Gynecology. 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Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Keratosis, Seborrheic - complications</topic><topic>Leiomyosarcoma - complications</topic><topic>Leiomyosarcoma - diagnosis</topic><topic>Medical sciences</topic><topic>Ovarian cancer</topic><topic>Paraneoplastic Syndromes - complications</topic><topic>Tumors</topic><topic>Uterine Neoplasms - complications</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abakka, Sanae, Dr</creatorcontrib><creatorcontrib>Elhalouat, Hatim, MD</creatorcontrib><creatorcontrib>Khoummane, Nadia, MD</creatorcontrib><creatorcontrib>Achaaban, Mouad, MD</creatorcontrib><creatorcontrib>ElAmrani, Sabah, Prof</creatorcontrib><creatorcontrib>Bargach, Samir, Prof</creatorcontrib><creatorcontrib>Yousfi, Mounia, 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The importance of Leser-Trélat sign is under debate because seborrhoeic keratoses and cancers are both common in elderly people.4 Yet the sign is regarded by many investigators as an independent paraneoplastic syndrome which is supported by reports of eruptive seborrhoeic keratoses in young patients, and by a strong association with well recognised paraneoplastic syndromes, such as malignant acanthosis nigricans and tripe palms.3 Recogniton of the sign in cases of occult cancer is important and we suggest that patients presenting with Leser-Trélat sign be thoroughly investigated for internal malignancy, especially gynaecological cancers in women.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23290965</pmid><doi>10.1016/S0140-6736(12)61805-4</doi><tpages>1</tpages></addata></record> |
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| subjects | Abdomen Aged Biological and medical sciences Female Female genital diseases General aspects Gynecology. Andrology. Obstetrics Humans Internal Medicine Keratosis, Seborrheic - complications Leiomyosarcoma - complications Leiomyosarcoma - diagnosis Medical sciences Ovarian cancer Paraneoplastic Syndromes - complications Tumors Uterine Neoplasms - complications Uterine Neoplasms - diagnosis Women |
| title | Uterine leiomyosarcoma and Leser-Trélat sign |
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