Uterine leiomyosarcoma and Leser-Trélat sign

The mainstay of treatment is total abdominal hysterectomy and bilateral salpingo-oophorectomy.2 Gynaecological cancers have rarely been associated with cutaneous paraneoplasia.3 The Leser-Trélat sign is a cutaneous paraneoplastic syndrome characterised by the sudden appearance of numerous seborrhoeic keratoses, or the rapid increase in size and number of preexisting lesions especially on the trunk. The importance of Leser-Trélat sign is under debate because seborrhoeic keratoses and cancers are both common in elderly people.4 Yet the sign is regarded by many investigators as an independent paraneoplastic syndrome which is supported by reports of eruptive seborrhoeic keratoses in young patients, and by a strong association with well recognised paraneoplastic syndromes, such as malignant acanthosis nigricans and tripe palms.3 Recogniton of the sign in cases of occult cancer is important and we suggest that patients presenting with Leser-Trélat sign be thoroughly investigated for internal malignancy, especially gynaecological cancers in women.