NICE clinical guideline (CG152): the management of Crohn's disease in adults, children and young people

Background The guideline offers best practice advice on the care of adults, children and young people with Crohn's disease. Aim To provide clinically effective and cost‐effective evidence‐based recommendations to guide clinical practice in a clinical guideline commissioned by the National Institute for Health and Clinical Excellence (NICE). Methods A systematic review of the evidence including critical appraisal, meta‐analysis and cost‐effectiveness modelling. Results Thirty‐one evidence‐based recommendations covering induction and maintenance therapy are available. Five key priorities for implementation are identified together with nine future research recommendations. Three guideline versions are available: short (containing just the recommendations), full (containing the full evidence base) and an Understanding NICE guidance for patients and carers. Algorithms have been produced together with a NICE pathway and implementation tools. Conclusion These are the first evidence‐based clinical and cost‐effectiveness guidelines for Crohn's disease in the United Kingdom.