Correlation between genotypic (V3 population sequencing) and phenotypic (Trofile ES) methods of characterizing co-receptor usage of HIV-1 from 200 treatment-naïve HIV patients screened for Study A4001078

► Assessment of tropism is needed to identify patients likely to respond to maraviroc. ► Concordance between tropism testing methods in screening samples was determined. ► Phenotypic and genotypic methods reported similar frequencies of R5 and non-R5 virus. ► Most samples had non-R5 HIV-1 RNA levels...

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Veröffentlicht in:	Antiviral research 2013-01, Vol.97 (1), p.60-65
Hauptverfasser:	Portsmouth, Simon, Valluri, Srinivas Rao, Däumer, Martin, Thiele, Bernhard, Valdez, Hernan, Lewis, Marilyn, Craig, Charles, Thielen, Alexander, James, Ian, Demarest, James, Heera, Jayvant
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Clinical trials CXCR5 Data processing Genotype Genotypes Genotyping High-Throughput Nucleotide Sequencing - methods HIV Infections - virology HIV-1 HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Maraviroc Medical sciences Pharmacology. Drug treatments Phenotype Population studies Prospective Studies Receptors, HIV - analysis RNA RNA, Viral - genetics Statistics Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology - methods Virus Attachment
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Beschreibung
Zusammenfassung:	► Assessment of tropism is needed to identify patients likely to respond to maraviroc. ► Concordance between tropism testing methods in screening samples was determined. ► Phenotypic and genotypic methods reported similar frequencies of R5 and non-R5 virus. ► Most samples had non-R5 HIV-1 RNA levels of
ISSN:	0166-3542 1872-9096
DOI:	10.1016/j.antiviral.2012.11.002