Palladium-Catalyzed Trifluoromethylation of Aromatic C–H Bond Directed by an Acetamino Group

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C–H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2013-01, Vol.15 (1), p.10-13
Hauptverfasser:	Zhang, Li-Sheng, Chen, Kang, Chen, Guihua, Li, Bi-Jie, Luo, Shuang, Guo, Qing-Yun, Wei, Jiang-Bo, Shi, Zhang-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - chemical synthesis Acetanilides - chemistry Aniline Compounds - chemical synthesis Aniline Compounds - chemistry Catalysis Hydrocarbons, Fluorinated - chemistry Molecular Structure Palladium - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C–H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol302814x