Synthesis of new 1-aryl-6-benzylimidazo[1,2-a][1,3,5]triazines with potential pharmacological activity

In the reaction of ethyl N-(1-arylimidazolidine-2-ylidene) carbamic acid ester with 4-chlorobenzylamine new derivatives of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea (I-VI) were obtained. Cyclic derivatives of dihydroimidazo[l ,2-a][1,3,5]trizines were synthesized by condensation of 1-(1-arylimida...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2012-11, Vol.69 (6), p.1270-1275
Hauptverfasser:	Rzadkowska, Marzena, Szacoń, Elzbieta, Matosiuk, Dariusz, Kedzierska, Ewa, Fidecka, Sylwia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemical synthesis Analgesics - pharmacology Animals Central Nervous System - drug effects Imidazoles - chemical synthesis Imidazoles - pharmacology Male Mice Motor Activity - drug effects Triazines - chemical synthesis Triazines - pharmacology
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Zusammenfassung:	In the reaction of ethyl N-(1-arylimidazolidine-2-ylidene) carbamic acid ester with 4-chlorobenzylamine new derivatives of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea (I-VI) were obtained. Cyclic derivatives of dihydroimidazo[l ,2-a][1,3,5]trizines were synthesized by condensation of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea with carbonyldiimidazole (CDI) (VII-XII). The effect of compounds X, XI on the central nervous system of mice in some behavioral tests was investigated.
ISSN:	0001-6837