Computer-Aided Detection of Metastatic Brain Tumors Using Magnetic Resonance Black-Blood Imaging

OBJECTIVESThe objective of this study was to develop a computer-aided detection system for automated brain metastases detection using magnetic resonance black-blood imaging and compare its applicability with conventional magnetization-prepared rapid gradient echo (MP-RAGE) imaging. MATERIALS AND METHODSTwenty-six patients with brain metastases were imaged with a contrast-enhanced, 3-dimensional, whole-brain magnetic resonance black-blood pulse sequence. Approval from the institutional review board and informed consent from the patients were obtained. Preprocessing steps included B1 inhomogeneity correction and brain extraction. The computer-aided detection system used 3-dimensional template matching, which measured normalized cross-correlation coefficient to generate possible metastases candidates. An artificial neural network was used for classification after various volume features were extracted. The same detection procedure was tested with contrast-enhanced MP-RAGE, which was also acquired from the same patients. RESULTSThe performance of the proposed detection method was measured by the area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity values. In the black-blood case, detection process displayed an AUROC of 0.9355, a sensitivity value of 81.1%, and a specificity value of 98.2%. Magnetization-prepared rapid gradient echo data showed an AUROC of 0.6508, a sensitivity value of 30.2%, and a specificity value of 99.97%. CONCLUSIONSThe results demonstrate that accurate automated detection of metastatic brain tumors using contrast-enhanced black-blood imaging sequence is possible compared with using conventional contrast-enhanced MP-RAGE sequence.