New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus
Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basi...
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| Veröffentlicht in: | Natural product communications 2012-11, Vol.7 (11), p.1431-1434 |
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| creator | Wang, Zenglei Gong, Wei Sun, Guoquan Tang, Hua Liu, Baoshu Li, Ling Yi, Yanghua Zhang, Wen |
| description | Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity. |
| doi_str_mv | 10.1177/1934578X1200701107 |
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The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X1200701107</identifier><identifier>PMID: 23285801</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Antifungal Agents - chemistry ; Antifungal Agents - isolation & purification ; Glycosides - chemistry ; Glycosides - isolation & purification ; Microbial Sensitivity Tests ; Molecular Structure ; Sea Cucumbers - chemistry ; Triterpenes - chemistry ; Triterpenes - isolation & purification</subject><ispartof>Natural product communications, 2012-11, Vol.7 (11), p.1431-1434</ispartof><rights>2012 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-465f391dbc460b00b6673e966fe428e4dae0e897b42ee467755dc7e0cd4c31603</citedby><cites>FETCH-LOGICAL-c387t-465f391dbc460b00b6673e966fe428e4dae0e897b42ee467755dc7e0cd4c31603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X1200701107$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X1200701107$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1934578X1200701107?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23285801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zenglei</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Sun, Guoquan</creatorcontrib><creatorcontrib>Tang, Hua</creatorcontrib><creatorcontrib>Liu, Baoshu</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Yi, Yanghua</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><title>New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus</title><title>Natural product communications</title><addtitle>Nat Prod Commun</addtitle><description>Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity.</description><subject>Animals</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Sea Cucumbers - chemistry</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EolXpH2BAHllC7cRfGasKWlAFA0ViixznQlMlcbATof57XLWwIHHL3fC8r3QPQteU3FEq5YymCeNSvdOYEEkoJfIMjSnnPEqZ5OfhDkB0IEZo6v2OhFGKEZZeolGcxIorQsdo8wxfeGVr63vdRv2-A7xxVQ-ugxbwst4b66sCPC6dbXC_BfwKGi8GMzQ5ODzvQrAyW9sNHj_pzraVGfwVuih17WF62hP09nC_Wayi9cvycTFfRyZRso-Y4GWS0iI3TJCckFwImUAqRAksVsAKDQRUKnMWAzAhJeeFkUBMwUxCBUkm6PbY2zn7OYDvs6byBupat2AHn9FYJkFPqlhA4yNqnPXeQZl1rmq022eUZAeh2V-hIXRz6h_yBorfyI--AMyOgNcfkO3s4Nrw73-V35bqfeA</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Wang, Zenglei</creator><creator>Gong, Wei</creator><creator>Sun, Guoquan</creator><creator>Tang, Hua</creator><creator>Liu, Baoshu</creator><creator>Li, Ling</creator><creator>Yi, Yanghua</creator><creator>Zhang, Wen</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus</title><author>Wang, Zenglei ; Gong, Wei ; Sun, Guoquan ; Tang, Hua ; Liu, Baoshu ; Li, Ling ; Yi, Yanghua ; Zhang, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-465f391dbc460b00b6673e966fe428e4dae0e897b42ee467755dc7e0cd4c31603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Sea Cucumbers - chemistry</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zenglei</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Sun, Guoquan</creatorcontrib><creatorcontrib>Tang, Hua</creatorcontrib><creatorcontrib>Liu, Baoshu</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Yi, Yanghua</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wang, Zenglei</au><au>Gong, Wei</au><au>Sun, Guoquan</au><au>Tang, Hua</au><au>Liu, Baoshu</au><au>Li, Ling</au><au>Yi, Yanghua</au><au>Zhang, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus</atitle><jtitle>Natural product communications</jtitle><addtitle>Nat Prod Commun</addtitle><date>2012-11</date><risdate>2012</risdate><volume>7</volume><issue>11</issue><spage>1431</spage><epage>1434</epage><pages>1431-1434</pages><issn>1934-578X</issn><eissn>1555-9475</eissn><abstract>Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23285801</pmid><doi>10.1177/1934578X1200701107</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Natural product communications, 2012-11, Vol.7 (11), p.1431-1434 |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antifungal Agents - chemistry Antifungal Agents - isolation & purification Glycosides - chemistry Glycosides - isolation & purification Microbial Sensitivity Tests Molecular Structure Sea Cucumbers - chemistry Triterpenes - chemistry Triterpenes - isolation & purification |
| title | New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus |
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