New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopus Japonicus

Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basi...

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Veröffentlicht in:	Natural product communications 2012-11, Vol.7 (11), p.1431-1434
Hauptverfasser:	Wang, Zenglei, Gong, Wei, Sun, Guoquan, Tang, Hua, Liu, Baoshu, Li, Ling, Yi, Yanghua, Zhang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemistry Antifungal Agents - isolation & purification Glycosides - chemistry Glycosides - isolation & purification Microbial Sensitivity Tests Molecular Structure Sea Cucumbers - chemistry Triterpenes - chemistry Triterpenes - isolation & purification
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Zusammenfassung:	Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1200701107