l-Carnitine and Long-Chain Acylcarnitines are Positively Correlated with Ambulatory Blood Pressure in Humans: The SABPA Study

The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l -carnitine in treatment has received much attention, studies reporting on physiological l -carnitine levels in hypertensives are limited. Our aim was to determine phys...

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Veröffentlicht in:	Lipids 2013, Vol.48 (1), p.63-73
Hauptverfasser:	Mels, Catharina M. C., Schutte, Aletta E., Erasmus, Elardus, Huisman, Hugo W., Schutte, Rudolph, Fourie, Carla M. T., Kruger, Ruan, Van Rooyen, Johannes M., Smith, Wayne, Malan, Nicolaas T., Malan, Leoné
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Continental Ancestry Group Ambulatory blood pressure Biomedical and Life Sciences Blood Pressure Blood Pressure Monitoring, Ambulatory Carnitine - analogs & derivatives Carnitine - blood Cross-Sectional Studies Ethnicity European Continental Ancestry Group Fatty acid metabolism Heart lipid metabolism Humans Hypertension - blood Life Sciences Lipid biochemistry Lipidology Long‐chain acylcarnitines l‐Carnitine Male Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics Middle Aged Neurochemistry Nuclear receptors Nutrition Original Article β‐Oxidation
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Zusammenfassung:	The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l -carnitine in treatment has received much attention, studies reporting on physiological l -carnitine levels in hypertensives are limited. Our aim was to determine physiological levels of l -carnitine and acylcarnitines in African and Caucasian men, and to investigate associations between ambulatory blood pressure (BP) and carnitine levels. Participants included 101 African and 101 Caucasian teachers. Ambulatory BP measurements were conducted, and l -carnitine and acylcarnitine levels determined. African men showed significantly higher systolic BP ( p
ISSN:	0024-4201 1558-9307
DOI:	10.1007/s11745-012-3732-8