An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle

Skeletal muscle regeneration in pathology and following injury requires the coordinated actions of inflammatory cells and myogenic cells to remove damaged tissue and rebuild syncytial muscle cells, respectively. Following contusion injury to muscle, the cytokine leukemia inhibitor factor (LIF) is up...

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Veröffentlicht in:	Histochemistry and cell biology 2013, Vol.139 (1), p.13-34
Hauptverfasser:	Hunt, Liam C., Upadhyay, Aradhana, Jazayeri, Jalal A., Tudor, Elizabeth M., White, Jason D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedical research Biomedicine Cell Biology Cells, Cultured Cellular biology Cytokines Cytokines - genetics Cytokines - metabolism Developmental Biology Elapid Venoms - pharmacology Gene Expression Regulation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Inflammation Mediators - metabolism Injections, Intraperitoneal Leukemia Leukemia Inhibitory Factor - administration & dosage Leukemia Inhibitory Factor - genetics Leukemia Inhibitory Factor - metabolism Leukemia Inhibitory Factor Receptor alpha Subunit - antagonists & inhibitors Leukemia Inhibitory Factor Receptor alpha Subunit - metabolism Macrophages - immunology Macrophages - metabolism Male Mast Cells - immunology Mast Cells - metabolism Mice Mice, Inbred C57BL Muscle Development - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Mutation Myogenin - genetics Myogenin - metabolism Neuromuscular diseases Neutrophils - immunology Neutrophils - metabolism Original Paper Recombinant Proteins - administration & dosage Regeneration - drug effects RNA, Messenger - metabolism Signal Transduction - drug effects Time Factors
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