Acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus

In order to investigate whether short- or long-term glycemic fluctuations could induce oxidative stress and chronic inflammation, we evaluated the relationships between glycemic variability, oxidative stress markers, and high-sensitivity C-reactive protein (hs-CRP). We enrolled 34 patients with type...

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Veröffentlicht in:Acta diabetologica 2012-12, Vol.49 (Suppl 1), p.171-177
Hauptverfasser: Chang, Chih-Min, Hsieh, Ching-Jung, Huang, Ju-Chun, Huang, I-Chin
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Sprache:eng
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Zusammenfassung:In order to investigate whether short- or long-term glycemic fluctuations could induce oxidative stress and chronic inflammation, we evaluated the relationships between glycemic variability, oxidative stress markers, and high-sensitivity C-reactive protein (hs-CRP). We enrolled 34 patients with type 2 diabetes. As a measure of short-term glycemic variability, mean amplitude of glycemic excursions (MAGE) was computed from continuous glucose monitoring system data. For determining long-term glycemic variability, we calculated the standard deviation (SD) of hemoglobin A1c (HbA1c) levels measured over a 2-year period. Levels of oxidative stress markers: 8-iso-prostaglandin F2α (8-iso-PGF2α), thiobarbituric acid-reactive substance (TBARS), 8-hydroxydeoxyguanosine (8-OHdG), and hs-CRP were measured. MAGE was significantly correlated with the SD of HbA1c levels ( r  = 0.73, p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-012-0398-x