Splenectomy and/or cyclophosphamide as salvage therapies in thrombotic thrombocytopenic purpura: the French TMA Reference Center experience

BACKGROUND: The objective was to assess the efficacy and safety of splenectomy and cyclophosphamide as salvage therapies in severe thrombotic thrombocytopenic purpura (TTP). STUDY DESIGN AND METHODS: During a 10‐year period, patients who did not improve with plasma exchanges, steroids, vincristine,...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2012-11, Vol.52 (11), p.2436-2444
Hauptverfasser:	Beloncle, François, Buffet, Marc, Coindre, Jean-Philippe, Munoz-Bongrand, Nicolas, Malot, Sandrine, Pène, Frédéric, Mira, Jean-Paul, Galicier, Lionel, Guidet, Bertrand, Baudel, Jean-Luc, Subra, Jean-François, Tanguy-Schmidt, Aline, Pourrat, Jacques, Azoulay, Elie, Veyradier, Agnès, Coppo, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemias. Hemoglobinopathies Biological and medical sciences Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Diseases of red blood cells Female Follow-Up Studies France - epidemiology Hematologic and hematopoietic diseases Humans Male Medical sciences Medical treatment Myeloablative Agonists - administration & dosage Myeloablative Agonists - adverse effects Platelet diseases and coagulopathies Pulse Therapy, Drug Purpura, Thrombotic Thrombocytopenic - drug therapy Purpura, Thrombotic Thrombocytopenic - mortality Registries - statistics & numerical data Remission Induction Salvage Salvage Therapy - methods Severity of Illness Index Splenectomy - methods Treatment Outcome
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