Splenectomy and/or cyclophosphamide as salvage therapies in thrombotic thrombocytopenic purpura: the French TMA Reference Center experience

Splenectomy and/or cyclophosphamide as salvage therapies in thrombotic thrombocytopenic purpura: the French TMA Reference Center experience

BACKGROUND: The objective was to assess the efficacy and safety of splenectomy and cyclophosphamide as salvage therapies in severe thrombotic thrombocytopenic purpura (TTP). STUDY DESIGN AND METHODS: During a 10‐year period, patients who did not improve with plasma exchanges, steroids, vincristine,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2012-11, Vol.52 (11), p.2436-2444
Hauptverfasser: Beloncle, François, Buffet, Marc, Coindre, Jean-Philippe, Munoz-Bongrand, Nicolas, Malot, Sandrine, Pène, Frédéric, Mira, Jean-Paul, Galicier, Lionel, Guidet, Bertrand, Baudel, Jean-Luc, Subra, Jean-François, Tanguy-Schmidt, Aline, Pourrat, Jacques, Azoulay, Elie, Veyradier, Agnès, Coppo, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anemias. Hemoglobinopathies
Biological and medical sciences
Cyclophosphamide - administration & dosage
Cyclophosphamide - adverse effects
Diseases of red blood cells
Female
Follow-Up Studies
France - epidemiology
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Medical treatment
Myeloablative Agonists - administration & dosage
Myeloablative Agonists - adverse effects
Platelet diseases and coagulopathies
Pulse Therapy, Drug
Purpura, Thrombotic Thrombocytopenic - drug therapy
Purpura, Thrombotic Thrombocytopenic - mortality
Registries - statistics & numerical data
Remission Induction
Salvage
Salvage Therapy - methods
Severity of Illness Index
Splenectomy - methods
Treatment Outcome
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BACKGROUND: The objective was to assess the efficacy and safety of splenectomy and cyclophosphamide as salvage therapies in severe thrombotic thrombocytopenic purpura (TTP). STUDY DESIGN AND METHODS: During a 10‐year period, patients who did not improve with plasma exchanges, steroids, vincristine, and/or rituximab were considered for splenectomy or cyclophosphamide. Patients with a documented severe (
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2012.03578.x