Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons

Background Endogenous opioids are implicated in pain‐regulation in chronic inflammatory bowel disease (IBD). We sought to examine whether endogenous opioids suppress the excitability of colonic nociceptive dorsal root ganglia (DRG) neurons during chronic IBD, and if so, whether modulation of underl...

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Veröffentlicht in:	Neurogastroenterology and motility 2013-01, Vol.25 (1), p.39-e4
Hauptverfasser:	Valdez‐Morales, E., Guerrero‐Alba, R., Ochoa‐Cortes, F., Benson, J., Spreadbury, I., Hurlbut, D., Miranda‐Morales, M., Lomax, A. E., Vanner, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Action Potentials - physiology Animals beta -Endorphin beta-Endorphin - metabolism beta-Endorphin - pharmacology CD4 antigen Cell Separation Chronic Disease Colitis Colon Colon - innervation Dextran sulfate Disease Models, Animal Dorsal root ganglia DSS colitis endogenous opioids Enkephalins Enzyme-Linked Immunosorbent Assay Excitability Flow Cytometry Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism IBD Immunohistochemistry Immunoreactivity Inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Mice Mice, Inbred C57BL Naloxone Narcotics Neurons Opioid receptors (type mu) Opioids Pain perception Patch-Clamp Techniques Potassium channels (voltage-gated) Rodents Sensory neurons Sodium
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Zusammenfassung:	Background Endogenous opioids are implicated in pain‐regulation in chronic inflammatory bowel disease (IBD). We sought to examine whether endogenous opioids suppress the excitability of colonic nociceptive dorsal root ganglia (DRG) neurons during chronic IBD, and if so, whether modulation of underlying voltage‐gated K+ currents was involved. Methods The effects of chronic dextran sulfate sodium (DSS) colitis on afferent signaling in mice was studied using patch clamp recordings. Colonic DRG neurons were identified using Fast Blue retrograde labeling and recordings obtained from small DRG neurons (
ISSN:	1350-1925 1365-2982
DOI:	10.1111/nmo.12008