Interleukin‐28B polymorphism in hepatitis C and liver transplantation

Interleukin‐28B polymorphism in hepatitis C and liver transplantation

The discovery of interleukin‐28B (IL‐28B) single‐nucleotide polymorphisms has opened an important new area of research in liver transplantation (LT) for hepatitis C virus (HCV). Both recipient‐ and donor‐derived IL‐28B genotypes affect the post‐LT treatment response, with sustained virological respo...

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Veröffentlicht in:Liver transplantation 2013-01, Vol.19 (1), p.49-58
Hauptverfasser: Duarte‐Rojo, Andres, Deneke, Matthew G., Charlton, Michael R.
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes Mellitus - etiology
Fatty Liver - etiology
Genotype
Graft Survival
Hepatitis C - genetics
Humans
Interferons
Interleukins - genetics
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Polymorphism, Single Nucleotide
Transplantation, Homologous
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Zusammenfassung:The discovery of interleukin‐28B (IL‐28B) single‐nucleotide polymorphisms has opened an important new area of research in liver transplantation (LT) for hepatitis C virus (HCV). Both recipient‐ and donor‐derived IL‐28B genotypes affect the post‐LT treatment response, with sustained virological response (SVR) rates oscillating from >50% in homozygotes for the favorable allele (up to 90% when this is present in both the recipient and the donor) to
ISSN:1527-6465
1527-6473
DOI:10.1002/lt.23554