Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells

Highlights ► TR3 is essential for the maintenance of stem-like properties in human gastric cancer. ► TR3 downregulates the gene expression of Oct-4, Nanog and MMP-9. ► Nanog is a new target for the transcription factor TR3.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-02, Vol.329 (1), p.37-44
Hauptverfasser:	Zhan, Yan-yan, He, Jian-ping, Chen, Hang-zi, Wang, Wei-jia, Cai, Jian-chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Base Sequence Binding sites Cell growth Cell Line, Tumor cell proliferation correlation Drug resistance Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques genes Hematology, Oncology and Palliative Medicine Homeodomain Proteins - genetics Humans Matrix Metalloproteinase 9 - genetics Metabolism Metastasis Mice Mice, Inbred BALB C Mice, Nude Molecular Sequence Data Nanog Nanog Homeobox Protein Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nuclear orphan receptor TR3 Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Octamer Transcription Factor-3 - genetics Promoter Regions, Genetic Spheres Stem cells Stem-like properties stomach neoplasms Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transcription factors Tumor Microenvironment - genetics Tumors Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Highlights ► TR3 is essential for the maintenance of stem-like properties in human gastric cancer. ► TR3 downregulates the gene expression of Oct-4, Nanog and MMP-9. ► Nanog is a new target for the transcription factor TR3.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.09.022