Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance

Highlights ► STC1 lacking mice are sicker than littermates after ischemic stroke. ► Hypoxic preconditioning works despite the lack of STC1. ► STC1 deficiency leads to lower expression of IL-6 in ischemic brain. ► STC1 is not an important component of the blood-brain barrier.

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Veröffentlicht in:Neuroscience 2013-01, Vol.229, p.49-54
Hauptverfasser: Durukan Tolvanen, A, Westberg, J.A, Serlachius, M, Chang, A.C.-M, Reddel, R.R, Andersson, L.C, Tatlisumak, T
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Sprache:eng
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Zusammenfassung:Highlights ► STC1 lacking mice are sicker than littermates after ischemic stroke. ► Hypoxic preconditioning works despite the lack of STC1. ► STC1 deficiency leads to lower expression of IL-6 in ischemic brain. ► STC1 is not an important component of the blood-brain barrier.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.10.062