Vaccination in children with inborn errors of metabolism

Highlights ► The impact of the available vaccines on children with IEMs may vary. ► Severe metabolic crises after vaccination have been rarely reported. ► Vaccines should be cautiously administered in IEMs with significant catabolic event. ► Immune deficiency in a number of IEMs may lead to an inade...

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Veröffentlicht in:	Vaccine 2012-11, Vol.30 (50), p.7161-7164
Hauptverfasser:	Menni, Francesca, Chiarelli, Gabriella, Sabatini, Caterina, Principi, Nicola, Esposito, Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy and Immunology Child Child, Preschool Children Children & youth Fatty acids Humans Immune response Immunization Schedule Inborn errors of metabolism Infant Infant, Newborn Metabolic disorders Metabolism, Inborn Errors - immunology Rare diseases Vaccination - methods Vaccinations Vaccines Vaccines - administration & dosage Vaccines - adverse effects Vaccines - immunology
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Beschreibung
Zusammenfassung:	Highlights ► The impact of the available vaccines on children with IEMs may vary. ► Severe metabolic crises after vaccination have been rarely reported. ► Vaccines should be cautiously administered in IEMs with significant catabolic event. ► Immune deficiency in a number of IEMs may lead to an inadequate immune response. ► Live attenuated viruses vaccines should not be given in IEMs with severe immunodeficiency.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.10.012