Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

Highlights ► Sialidase activity of H1N1/09 and other human, swine and avian viruses was studied. ► 7:1 recombinant H1N1/09 viruses harboring different NAs were prepared and compared. ► H1N1/09 NA has distinctive substrate specificity. ► H1N1/09 NA and classical swine virus NA have similar functional...

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Veröffentlicht in:	Vaccine 2012-12, Vol.30 (51), p.7348-7352
Hauptverfasser:	Gerlach, T, Kühling, L, Uhlendorff, J, Laukemper, V, Matrosovich, T, Czudai-Matwich, V, Schwalm, F, Klenk, H.-D, Matrosovich, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Allergy and Immunology birds Catalytic activity Cell culture Data processing Erythrocytes Evolution, Molecular Exo- alpha -sialidase functional properties Genes HA/NA balance Humans hydrolysis Infections Influenza Influenza A Virus, H1N1 Subtype - enzymology Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - pathogenicity Influenza virus Influenza, Human - virology Kinetics mucin Mucins Neuraminidase Neuraminidase - genetics Neuraminidase - metabolism Neutralization Orthomyxoviridae pandemic Pandemics Plasmids Recombination, Genetic Respiratory tract Seasonal variations Sialic Acids - metabolism sialidase Sulfur dioxide swine Swine flu Vaccines vertebrate viruses Viral Proteins - genetics Viral Proteins - metabolism Virulence Factors - genetics Virulence Factors - metabolism Viruses
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Beschreibung
Zusammenfassung:	Highlights ► Sialidase activity of H1N1/09 and other human, swine and avian viruses was studied. ► 7:1 recombinant H1N1/09 viruses harboring different NAs were prepared and compared. ► H1N1/09 NA has distinctive substrate specificity. ► H1N1/09 NA and classical swine virus NA have similar functional characteristics.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.09.078