Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

Highlights ► Protease inhibitors provide novel drugs for influenza A and B virus treatment.► Combination chemotherapy using protease inhibitors and neuraminidase inhibitors.► Host factor-directed drugs for influenza treatment.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-12, Vol.30 (51), p.7374-7380
Hauptverfasser:	Böttcher-Friebertshäuser, Eva, Lu, Yinghui, Meyer, Daniela, Sielaff, Frank, Steinmetzer, Torsten, Klenk, Hans-Dieter, Garten, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibiotics Antiviral Agents - metabolism Cell Line Chemotherapy Dipeptides - metabolism drug therapy Drugs Enzymes Epithelial cells Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - virology Exo- alpha -sialidase Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hemagglutinins Humans Infection Infections Infectivity Influenza Influenza A Influenza A virus - physiology Influenza B virus Influenza B virus - physiology Influenza virus Laboratories Oseltamivir Pandemics pathogenicity Peptide mimetic protease inhibitors Peptides Propagation Protease Inhibitors - metabolism Proteinase Proteinase inhibitors proteinases Proteolytic activation Replication Respiratory tract Serine Endopeptidases - metabolism sialidase Substance abuse treatment Sulfonamides - metabolism Swine flu TMPRSS2 vaccines viral load Virology Virus Attachment virus replication Viruses
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Beschreibung
Zusammenfassung:	Highlights ► Protease inhibitors provide novel drugs for influenza A and B virus treatment.► Combination chemotherapy using protease inhibitors and neuraminidase inhibitors.► Host factor-directed drugs for influenza treatment.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.10.001