Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases

Graphical abstract Highlights ► Immunomodulatory properties of MSCs in vitro and in vivo are discussed. ► Safety and efficacy of treatments with allogeneic MSCs are discussed. ► Future directions to improve efficacy of MSC treatments are proposed.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in biotechnology 2012-12, Vol.23 (6), p.978-983
Hauptverfasser:	DelaRosa, Olga, Dalemans, Wilfried, Lombardo, Eleuterio
Format:	Artikel
Sprache:	eng
Schlagworte:	adults animal models Animals autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - therapy Cell Transformation, Neoplastic clinical trials Humans immunomodulators Inflammation - immunology Inflammation - therapy Internal Medicine Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stromal Cells - immunology Mesenchymal Stromal Cells - pathology stem cells stromal cells therapeutics Transplantation, Homologous Treatment Outcome
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► Immunomodulatory properties of MSCs in vitro and in vivo are discussed. ► Safety and efficacy of treatments with allogeneic MSCs are discussed. ► Future directions to improve efficacy of MSC treatments are proposed.
ISSN:	0958-1669 1879-0429
DOI:	10.1016/j.copbio.2012.05.005