Alteration of immune function endpoints and differential expression of estrogen receptor isoforms in leukocytes from 17β-estradiol exposed rainbow trout ( Oncorhynchus mykiss )

Highlights ► We assessed effects of 17β-estradiol (E2) on the immune system of rainbow trout. ► Hematocrit and lymphocyte proliferation were altered by E2 treatment. ► Estrogen receptors were present in leukocytes and ERα was differentially regulated. ► All parameters returned to control levels with...

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Veröffentlicht in:	General and comparative endocrinology 2013-01, Vol.180 (1), p.24-32
Hauptverfasser:	Shelley, Lesley K, Osachoff, Heather L, van Aggelen, Graham C, Ross, Peter S, Kennedy, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-estradiol Animals aquatic environment Cell Proliferation - drug effects endocrine system Endocrinology & Metabolism estradiol Estradiol - pharmacology Estrogen receptor estrogen receptors exposure duration Female gene expression regulation hematocrit Immune system immunotoxicity kidneys leukocytes Leukocytes - drug effects Leukocytes - metabolism Lymphocyte proliferation Male messenger RNA Oncorhynchus mykiss Oncorhynchus mykiss - metabolism Rainbow trout Receptors, Estrogen - metabolism Recovery Teleostei trout
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Zusammenfassung:	Highlights ► We assessed effects of 17β-estradiol (E2) on the immune system of rainbow trout. ► Hematocrit and lymphocyte proliferation were altered by E2 treatment. ► Estrogen receptors were present in leukocytes and ERα was differentially regulated. ► All parameters returned to control levels within 14 d post-7d E2 exposure. ► At physiologically-relevant concentrations, E2 reversibly affects immune responses.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2012.09.014