MyD88-dependent interleukin-10 production from regulatory CD11b+ Gr-1high cells suppresses development of acute cerulein pancreatitis in mice

MyD88-dependent interleukin-10 production from regulatory CD11b+ Gr-1high cells suppresses development of acute cerulein pancreatitis in mice

Highlights ► MyD88−/− mice developed severer cerulein-induced pancreatitis. ► CD11b+ Gr-1high cells emerge in the pancreas of cerulein-administered mice. ► IL-10-producing CD11b+ Gr-1high cells emerge independently of commensal bacteria.

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Veröffentlicht in:Immunology letters 2012-12, Vol.148 (2), p.172-177
Hauptverfasser: Koike, Yuji, Kanai, Takanori, Saeki, Keita, Nakamura, Yuji, Nakano, Masaru, Mikami, Yohei, Yamagishi, Yoshiyuki, Nakamoto, Nobuhiro, Ebinuma, Hirotoshi, Hibi, Toshifumi
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Cerulein
IL-10
Macrophage
MyD88
Pancreatitis
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Zusammenfassung:Highlights ► MyD88−/− mice developed severer cerulein-induced pancreatitis. ► CD11b+ Gr-1high cells emerge in the pancreas of cerulein-administered mice. ► IL-10-producing CD11b+ Gr-1high cells emerge independently of commensal bacteria.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.08.008