Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

Immunodiscordant HIV-infected patients show viral suppression during antiretroviral therapy but fail to recover CD4 T cells. Immunodiscordance is characterized by partial CD4 T-cell immunodeficiency and increased inflammation, activation and immunosenescence in both CD4 and CD8 T cells. A randomized...

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Veröffentlicht in:	AIDS (London) 2012-11, Vol.26 (18), p.2285-2293
Hauptverfasser:	MASSANELLA, Marta, NEGREDO, Eugenia, PUIG, Jordi, PUERTAS, Maria C, BUZON, Maria J, PEREZ-ALVAREZ, Núria, CARRILLO, Jorge, CLOTET, Bonaventura, MARTINEZ-PICADO, Javier, BLANCO, Julià
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral therapy Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences CD14 antigen CD38 antigen CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell activation Cell death Female Flow Cytometry Ganciclovir - analogs & derivatives Ganciclovir - pharmacology Histocompatibility antigen HLA HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Hydroxychloroquine - pharmacology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunodeficiency Immunopathology Immunosenescence Infectious diseases Inflammation Inflammation - drug therapy Inflammation - immunology Lymphocyte Activation - drug effects Lymphocytes T Male Medical sciences Memory cells Middle Aged Pharmacology. Drug treatments Prospective Studies Pyrrolidinones - administration & dosage Pyrrolidinones - pharmacology Raltegravir Potassium Thymus Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Zusammenfassung:	Immunodiscordant HIV-infected patients show viral suppression during antiretroviral therapy but fail to recover CD4 T cells. Immunodiscordance is characterized by partial CD4 T-cell immunodeficiency and increased inflammation, activation and immunosenescence in both CD4 and CD8 T cells. A randomized, controlled, 48-week intensification study to assess the effect of raltegravir on immunological parameters in immunodiscordant patients (CD4 cell counts
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e328359f20f