Detection and molecular characterization of hepatitis E virus in clinical, environmental and putative animal sources

Putative animal reservoirs and environmental samples were studied to investigate potential routes of transmission for indigenous hepatitis E virus (HEV) infection in Hokkaido, Japan. A total of 468 liver samples and 954 environmental samples were collected from 2003 to 2011 for this study. Four swin...

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Veröffentlicht in:	Archives of virology 2012-12, Vol.157 (12), p.2363-2368
Hauptverfasser:	Ishida, Setsuko, Yoshizumi, Shima, Ikeda, Tetsuya, Miyoshi, Masahiro, Goto, Akiko, Matsubayashi, Keiji, Ikeda, Hisami
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood & organ donations Brief Report Deer Disease Reservoirs - virology Food Microbiology Fundamental and applied biological sciences. Psychology Genetic diversity Genetic Variation Genotype Genotype & phenotype Health facilities Hepatitis Hepatitis E - epidemiology Hepatitis E - veterinary Hepatitis E - virology Hepatitis E virus Hepatitis E virus - classification Hepatitis E virus - genetics Hogs Humans Infections Infectious Diseases Japan - epidemiology Liver Liver - virology Medical Microbiology Microbiology Miscellaneous Molecular Sequence Data Norgestrel - analogs & derivatives Ostreidae - virology Oysters Phylogeny Rivers - virology RNA, Viral - isolation & purification Seawater Seawater - virology Sewage - virology Swine Swine Diseases - epidemiology Swine Diseases - virology Virology Viruses
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Beschreibung
Zusammenfassung:	Putative animal reservoirs and environmental samples were studied to investigate potential routes of transmission for indigenous hepatitis E virus (HEV) infection in Hokkaido, Japan. A total of 468 liver samples and 954 environmental samples were collected from 2003 to 2011 for this study. Four swine livers (1 %) were positive for HEV RNA; two strains belonged to genotype 3 and the other two strains were genotype 4. Genotype 3 HEV was detected in a sewage sample and a seawater sample. HEV strains derived from swine liver, seawater and raw sewage samples shared 93-100 % sequence similarity with human HEV strains.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-012-1422-8