Soy isoflavones (daidzein & genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice

Graphical abstract Highlights ► Soy isoflavones (SIF) inhibit TPA-induced hyperproliferation. ► SIF abrogates TPA-induced histopathological alterations of the skin. ► SIF inhibits TPA-induced oxidative stress and inflammation. ► SIF attenuates TPA-induced expression of NF-κB, COX-2 and ki-67....

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Veröffentlicht in:	Toxicology (Amsterdam) 2012-12, Vol.302 (2-3), p.266-274
Hauptverfasser:	Khan, Abdul Quaiyoom, Khan, Rehan, Rehman, Muneeb U, Lateef, Abdul, Tahir, Mir, Ali, Farrah, Sultana, Sarwat
Format:	Artikel
Sprache:	eng
Schlagworte:	acetone Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Proliferation - drug effects Chemical agents chronic diseases Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism cytokines daidzein Dermatitis - drug therapy Dermatitis - etiology Emergency Female genistein Genistein - pharmacology Glycine max - chemistry Inflammation Inflammation - drug therapy Inflammation - etiology Isoflavones Isoflavones - pharmacology Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Medical sciences Mice NF-kappa B - genetics NF-kappa B - metabolism NF-κB oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Proinflammatory cytokines protective effect Skin - drug effects Skin - pathology Tetradecanoylphorbol Acetate - adverse effects topical application toxicity Toxicology transcription factor NF-kappa B Tumors
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Zusammenfassung:	Graphical abstract Highlights ► Soy isoflavones (SIF) inhibit TPA-induced hyperproliferation. ► SIF abrogates TPA-induced histopathological alterations of the skin. ► SIF inhibits TPA-induced oxidative stress and inflammation. ► SIF attenuates TPA-induced expression of NF-κB, COX-2 and ki-67.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2012.08.008