Differentially expressed miRNAs in retinoblastoma

MicroRNAs (miRNAs) are short non-coding RNA transcripts that have the ability to regulate the expression of target genes, and have been shown to influence the development of various tumors. The purpose of our study is to identify aberrantly expressed miRNAs in retinoblastoma for the discovery of pot...

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Veröffentlicht in:	Gene 2013-01, Vol.512 (2), p.294-299
Hauptverfasser:	Martin, Joshua, Bryar, Paul, Mets, Marilyn, Weinstein, Joanna, Jones, Aunica, Martin, Alissa, Vanin, Elio F., Scholtens, Denise, Costa, Fabricio F., Soares, Marcelo B., Laurie, Nikia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cell Line, Tumor Female gene expression regulation Gene Expression Regulation, Neoplastic genes Humans Male messenger RNA Mice MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics miRNA neoplasms non-coding RNA Retina Retinal Neoplasms - genetics Retinal Neoplasms - metabolism Retinal Neoplasms - pathology retinoblastoma Retinoblastoma - genetics Retinoblastoma - metabolism Retinoblastoma - pathology retinoblastoma cells RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Taqman low density array Tumors
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Beschreibung
Zusammenfassung:	MicroRNAs (miRNAs) are short non-coding RNA transcripts that have the ability to regulate the expression of target genes, and have been shown to influence the development of various tumors. The purpose of our study is to identify aberrantly expressed miRNAs in retinoblastoma for the discovery of potential therapeutic targets for this disease, and to gain a greater understanding of the mechanisms driving retinoblastoma progression. We report 41 differentially expressed miRNAs (p
ISSN:	0378-1119 1879-0038
DOI:	10.1016/j.gene.2012.09.129