Gossypol-induced suicidal erythrocyte death

Gossypol-induced suicidal erythrocyte death

Graphical abstract Highlights ► The male contraceptive gossypol increases cytosolic Ca2+ -activity in erythrocytes. ► Gossypol decreases erythrocyte cell volume. ► Gossypol triggers slight hemolysis. ► Gossypol stimulates erythrocyte membrane scrambling with phosphatidylserine exposure. ► The effect...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicology (Amsterdam) 2012-12, Vol.302 (2-3), p.101-105
Hauptverfasser: Zbidah, Mohanad, Lupescu, Adrian, Shaik, Nazneen, Lang, Florian
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
adverse effects
anemia
Aniline Compounds - analysis
Annexin A5 - metabolism
antiviral properties
Apoptosis - drug effects
Biological and medical sciences
Calcium
Calcium - metabolism
Cell Death
Cell Membrane - drug effects
Cell Membrane - metabolism
cell membranes
Cell Size - drug effects
Cell volume
Cytosol - metabolism
Emergency
Eryptosis
erythrocytes
Erythrocytes - cytology
Erythrocytes - drug effects
Flow Cytometry
fluorescence
Gossypium
Gossypol
Gossypol - toxicity
hemoglobin
hemolysis
Hemolysis - drug effects
Humans
Medical sciences
Phosphatidylserine
Phosphatidylserines - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
shrinkage
Suicide
Toxicology
Xanthenes - analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Graphical abstract Highlights ► The male contraceptive gossypol increases cytosolic Ca2+ -activity in erythrocytes. ► Gossypol decreases erythrocyte cell volume. ► Gossypol triggers slight hemolysis. ► Gossypol stimulates erythrocyte membrane scrambling with phosphatidylserine exposure. ► The effect on cell membrane scrambling is blunted by removal of extracellular Ca2+.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2012.09.010