Subpopulation of Colorectal Adenocarcinoma Cells Co-Expressing CD133 and Cancer Stem Cells Markers of Other Tumors

Co-expression of colorectal adenocarcinoma cancer stem cells marker CD133 and a set of surface molecules described in published reports as possible cancer stem cell markers of other solid tumors was analyzed by fl ow cytometry. Minor cell populations expressing CD29, CD34, CD90, and CD117 against th...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-04, Vol.152 (6), p.739-742
Hauptverfasser: Gisina, A. M., Lupatov, A. Yu, Karalkin, P. A., Mainovskaya, O. A., Petrov, L. O., Sidorov, D. V., Frank, G. A., Yarygin, K. N.
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Sprache:eng
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Zusammenfassung:Co-expression of colorectal adenocarcinoma cancer stem cells marker CD133 and a set of surface molecules described in published reports as possible cancer stem cell markers of other solid tumors was analyzed by fl ow cytometry. Minor cell populations expressing CD29, CD34, CD90, and CD117 against the background of CD133 expression were detected in cancer cells suspensions from the patients with colorectal adenocarcinoma. Our fi ndings suggest that these markers can be used as additional markers of cancer stem cells of human colorectal adenocarcinoma.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1620-0