Ultrastructural reactions of liver cell populations induced by RNA-containing hepatitis C and DNA-containing hepatitis B viruses

Ultrastructural reactions of liver cell populations induced by RNA-containing hepatitis C and DNA-containing hepatitis B viruses

Combined hepatitis C and B virus infection is associated with phenotypic heterogeneity of hepatocyte populations. Patchy distribution of hepatocyte ultrastructural changes is due to the diversity of complex cytopathic effects of these viruses. RNA-containing hepatitis C virus impairs mainly the cyto...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1999-07, Vol.128 (1), p.747-750
Hauptverfasser: Nepomnyashchikh, G. I., Tolokonskaya, N. P., Aidagulova, C. V., Nepomnyashchikh, D. L., Sakharova, E. G., Mezentseva, G. A., Savchenko, Ya. E.
Format: Artikel
Sprache:eng
Schlagworte:
Deoxyribonucleic acid
DNA
Hepatitis
Hepatitis B
Hepatitis B virus
Hepatitis C
Hepatitis C virus
Hepatocytes
Infection
Liver
Nuclei
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Zusammenfassung:Combined hepatitis C and B virus infection is associated with phenotypic heterogeneity of hepatocyte populations. Patchy distribution of hepatocyte ultrastructural changes is due to the diversity of complex cytopathic effects of these viruses. RNA-containing hepatitis C virus impairs mainly the cytoplasmic compartment of liver parenchymal cells and does not affect the nucleus. DNA-containing hepatitis B virus induces degradation of the nuclear compartment.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433334