Evidence for anti-inflammatory and putative analgesic effects of a monoclonal antibody to calcitonin gene-related peptide

Highlights ► CGRP is a powerful pro-inflammatory mediator implicated in the development of pain. ► Our pulpal inflammation/Fos model is able to predict analgesic efficacy. ► An antibody to CGRP reduces leucocyte infiltration and brainstem neuron activation. ► This is the first direct evidence that C...

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Veröffentlicht in:	Neuroscience 2013-01, Vol.228, p.271-282
Hauptverfasser:	Bowler, K.E, Worsley, M.A, Broad, L, Sher, E, Benschop, R, Johnson, K, Yates, J.M, Robinson, P.P, Boissonade, F.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analgesics - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use antibody therapy Biological and medical sciences calcitonin gene-related peptide Calcitonin Gene-Related Peptide - antagonists & inhibitors Calcitonin Gene-Related Peptide - immunology Calcitonin Gene-Related Peptide - metabolism Dental Pulp - immunology Dental Pulp - metabolism Female Ferrets Fos Fundamental and applied biological sciences. Psychology Humans immunoneutralisation Inflammation - immunology Inflammation - metabolism Inflammation - therapy inflammatory pain Neurology Pain Measurement - methods Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Treatment Outcome trigeminal Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► CGRP is a powerful pro-inflammatory mediator implicated in the development of pain. ► Our pulpal inflammation/Fos model is able to predict analgesic efficacy. ► An antibody to CGRP reduces leucocyte infiltration and brainstem neuron activation. ► This is the first direct evidence that CGRP sequestration reduces inflammation. ► These data suggest that the anti-CGRP antibody has analgesic effects.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.10.030