Unique features of extracellular matrix in the mouse medial nucleus of trapezoid body – Implications for physiological functions

Highlights ► We studied the ECM of PNs in the MNTB of the auditory system in detail. ► Every MNTB neuron is surrounded by a remarkably prominent PN. ► We discovered a new distinct structural phenotype of PNs in MNTB. ► The Proteoglycans aggrecan and brevican show unique/differing spatial positions....

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Veröffentlicht in:	Neuroscience 2013-01, Vol.228, p.215-234
Hauptverfasser:	Blosa, M, Sonntag, M, Brückner, G, Jäger, C, Seeger, G, Matthews, R.T, Rübsamen, R, Arendt, T, Morawski, M
Format:	Artikel
Sprache:	eng
Schlagworte:	aggrecan Animals Auditory Pathways - physiology Auditory Pathways - ultrastructure Biochemistry and metabolism Biological and medical sciences Brain Stem - physiology Brain Stem - ultrastructure brevican calyx of Held Central nervous system chondroitin sulfate proteoglycans Extracellular Matrix - physiology Extracellular Matrix - ultrastructure Fundamental and applied biological sciences. Psychology glutamate Mice Mice, Inbred C57BL Neurology perineuronal net Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► We studied the ECM of PNs in the MNTB of the auditory system in detail. ► Every MNTB neuron is surrounded by a remarkably prominent PN. ► We discovered a new distinct structural phenotype of PNs in MNTB. ► The Proteoglycans aggrecan and brevican show unique/differing spatial positions. ► Our data support the hypothesis that PNs affect physiological functions of neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.10.003