Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: A role for hippocampal cell proliferation

Highlights ► BALB/cOLaHsd mice do not respond to chronic desipramine treatment in the NIH. ► Addition of lithium to desipramine induced antidepressant-like behaviour in the NIH. ► Lithium plus desipramine but neither drug alone increased hippocampal cell proliferation. ► Hippocampal neurogenesis may...

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Veröffentlicht in:	Neuroscience 2013-01, Vol.228, p.36-46
Hauptverfasser:	O’Leary, O.F, Zandy, S, Dinan, T.G, Cryan, J.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antidepressant augmentation behaviour Biological and medical sciences Cell Proliferation - drug effects Depressive Disorder, Treatment-Resistant - drug therapy Depressive Disorder, Treatment-Resistant - pathology Depressive Disorder, Treatment-Resistant - psychology Desipramine - administration & dosage Disease Models, Animal Drug Synergism Drug Therapy, Combination hippocampal neurogenesis Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology lithium Lithium Carbonate - administration & dosage Male Medical sciences Mice Mice, Inbred BALB C Neurology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Treatment Outcome treatment-resistant depression
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Zusammenfassung:	Highlights ► BALB/cOLaHsd mice do not respond to chronic desipramine treatment in the NIH. ► Addition of lithium to desipramine induced antidepressant-like behaviour in the NIH. ► Lithium plus desipramine but neither drug alone increased hippocampal cell proliferation. ► Hippocampal neurogenesis may contribute to lithium augmentation of antidepressants.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.072