Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer

Aims: To investigate the relationship between the expression of autophagy‐related proteins, including beclin‐1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer. Methods and results: We constructed tissue microarrays from the breast cancer cells of 489 patients, and cl...

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Veröffentlicht in:	Histopathology 2013-01, Vol.62 (2), p.275-286
Hauptverfasser:	Choi, Junjeong, Jung, Woohee, Koo, Ja Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Apoptosis Regulatory Proteins - metabolism Autophagy Beclin-1 Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - secondary DNA, Neoplasm - analysis Female Gynecology. Andrology. Obstetrics Humans immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Lymph Nodes - pathology Mammary gland diseases Medical research Medical sciences Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Middle Aged molecular subtype Neoplasm Proteins - metabolism Neoplasm Recurrence, Local Neoplasm Staging Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Republic of Korea - epidemiology Sequestosome-1 Protein Survival Rate Tissue Array Analysis Tumors
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Zusammenfassung:	Aims: To investigate the relationship between the expression of autophagy‐related proteins, including beclin‐1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer. Methods and results: We constructed tissue microarrays from the breast cancer cells of 489 patients, and classified molecular subtypes using surrogate immunohistochemical stains. The tumoral expression levels of LC3A and LC3B were highest in triple‐negative breast cancer (TNBC) (P
ISSN:	0309-0167 1365-2559
DOI:	10.1111/his.12002