Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior

Angelica archangelica Linn. (Apiaceae) is an herb distributed in tropical and subtropical regions of the world. Both in Chinese and Indian system of medicine, it is used for nervous disorders including anxiety, anorexia, migraine and other cerebral diseases. To evaluate the anxiolytic potential of non polar coumarins isolated from A. archangelica Linn. A. archangelica Linn. (1kg) was subjected to extraction in a soxhlet apparatus with petroleum ether (40–60 °C), yield 6.9% w/w. The extract of petroleum ether produced a yellow colored precipitate (YP) which was evaluated for anxiolytic like effect using EPM test and was found significant (**P