Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines

By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, o...

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Veröffentlicht in:	Organic & biomolecular chemistry 2013-01, Vol.11 (3), p.412-415
Hauptverfasser:	Zheng, Yongsheng, Xue, Zhouyang, Liu, Lixin, Shu, Chang, Yuan, Weicheng, Zhang, Xiaomei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Amines - pharmacology Catalysis Lewis Bases - chemistry Molecular Structure Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Stereoisomerism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, one of the products was employed in the synthesis of a pharmaceutical substance.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c2ob26672e