Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line

Here we describe, for the first time, adipolin expression in human chondrocytes as well as the intracellular mechanism involved in its regulation. [...]we show that adipolin expression is modulated by pro- and anti-inflammatory factors in chondrocytes.

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Veröffentlicht in:	Annals of the rheumatic diseases 2013-01, Vol.72 (1), p.140-142
Hauptverfasser:	Conde, Javier, Scotece, Morena, López, Verónica, Gómez, Rodolfo, Lago, Francisca, Pino, Jesús, Gómez-Reino, Juan Jesús, Gualillo, Oreste
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - genetics Adipokines - metabolism Animals Biological and medical sciences Cell Differentiation - physiology Cell Line Chondrocytes - cytology Chondrocytes - metabolism Diseases of the osteoarticular system Gene expression Gene Expression Regulation Humans Medical sciences Mice Obesity Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Rodents
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Beschreibung
Zusammenfassung:	Here we describe, for the first time, adipolin expression in human chondrocytes as well as the intracellular mechanism involved in its regulation. [...]we show that adipolin expression is modulated by pro- and anti-inflammatory factors in chondrocytes.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/annrheumdis-2012-201693