Antitumor activities of recombinant human interferon (IFN)-[lambda]1 in vitro and in xenograft models in vivo for colon cancer

Antitumor activities of recombinant human interferon (IFN)-[lambda]1 in vitro and in xenograft models in vivo for colon cancer

Highlights * rhIFN-λ1 inhibited the proliferation of colon cancer cells, HCT116 and HT29 in vitro. * It prolonged the duration of activated STATs and induced apoptosis in both cells. * rhIFN-λ1 suppressed tumor growth in a dose-dependent fashion in xenograft models. * Its inhibition rate is 52% for...

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Veröffentlicht in:Cancer letters 2011-12, Vol.311 (2), p.141-151
Hauptverfasser: Hui, Xiwu, Chen, Hong, Zhang, Shenghua, Ma, Xiaoli, Wang, Xin, Huang, Bingren
Format: Artikel
Sprache:eng
Schlagworte:
alpha -Interferon
Antitumor activity
Apoptosis
Cell culture
Cell proliferation
Colon
Colon cancer
Colorectal cancer
Interferon
Proteins
Rodents
Tumors
Xenografts
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Zusammenfassung:Highlights * rhIFN-λ1 inhibited the proliferation of colon cancer cells, HCT116 and HT29 in vitro. * It prolonged the duration of activated STATs and induced apoptosis in both cells. * rhIFN-λ1 suppressed tumor growth in a dose-dependent fashion in xenograft models. * Its inhibition rate is 52% for HCT116 and 56% for HT29in vivo. * rhIFN-λ1 could be a new potential reagent for cancer therapy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.07.004