Pathogen inactivation technology applied to a blood component collected from an asymptomatic carrier of Leishmania infantum: a case report

Asymptomatic Leishmania infections have been the main cause of transfusion transmission in endemic areas. Polymerase chain reaction has been used to detect L. infantum DNA in the peripheral blood of asymptomatic Leishmania carriers. In our region, the prevalence of asymptomatic L. infantum infection...

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Veröffentlicht in:Vox sanguinis 2012-11, Vol.103 (4), p.356-358
Hauptverfasser: Jimenez‐Marco, T., Fisa, R., Riera, C., Girona‐Llobera, E., Sedeño, M., Saura, A., Iniesta, L., Guillen, C., Muncunill, J.
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Sprache:eng
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Zusammenfassung:Asymptomatic Leishmania infections have been the main cause of transfusion transmission in endemic areas. Polymerase chain reaction has been used to detect L. infantum DNA in the peripheral blood of asymptomatic Leishmania carriers. In our region, the prevalence of asymptomatic L. infantum infection in donors is markedly high (5·9% of donors studied). We investigated the ability of pathogen inactivation technology, using amotosalen and UVA illumination, to eliminate L. infantum in a blood component collected from an asymptomatic L. infantum infected donor. This is the first report of the INTERCEPT system being used to eliminate a parasite from a component collected from a donor.
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2012.01622.x