Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

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Veröffentlicht in:	Leukemia 2012-12, Vol.26 (12), p.2546-2549
Hauptverfasser:	Xu, S, Evans, H, Buckle, C, De Veirman, K, Hu, J, Xu, D, Menu, E, De Becker, A, Vande Broek, I, Leleu, X, Camp, B V, Croucher, P, Vanderkerken, K, Van Riet, I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532/1360 631/80/86 692/699/2743/316 692/699/67/1990/804 Animals Biological and medical sciences Biomedical materials Bone Marrow - metabolism Bone Marrow - pathology Bones Cancer Research Cell Differentiation Cellular signal transduction Colony-Forming Units Assay Critical Care Medicine Cytokines Deactivation Differentiation (biology) Fetus - pathology Gene expression Growth Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Intensive Internal Medicine letter-to-the-editor Letters to the editor Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice Mice, Inbred C57BL Mineralization Multiple myeloma Multiple Myeloma - metabolism Multiple Myeloma - pathology Oncology Osteogenesis Physiological aspects Receptors, Notch - antagonists & inhibitors Receptors, Notch - genetics Signal Transduction Stem cells Tumor Cells, Cultured
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ISSN:	0887-6924 1476-5551
DOI:	10.1038/leu.2012.126